As per my knowledge, horses and donkeys belong to the same family, Equidae, which indicates that they can mate and produce offspring. However, their offspring are not true hybrids but are called mules or hinnies, depending on the sex of the parents. A mule is the offspring of a male donkey and a female horse, while a hinny is the offspring of a male horse and a female donkey. Mules and hinnies are sterile, meaning that they cannot reproduce because their parents have a different number of chromosomes that cause their offspring to produce nonviable eggs or sperm.

Although horses and donkeys can mate, this act is discouraged as it can be harmful to both the mare and the jenny, as well as the resulting offspring. In addition, while it is possible to see horses and donkeys mate in the wild or domestic settings, it is not recommended. Thus, while these two species can mate and produce offspring, their offspring are sterile, and the mating of horses and donkeys is generally not advised due to the harm it can cause.
A mule is the offspring of a male donkey (jack) and a female horse (mare), while a hinny is the offspring of a male horse (stallion) and a female donkey (jenny). The main difference between a mule and a hinny is that a mule tends to be larger and stronger than a hinny, and they have more horse-like features.
Mules and hinnies are sterile, which means they cannot reproduce. This is because horses and donkeys have a different number of chromosomes, which means that their offspring are usually unable to produce viable eggs or sperm.
Despite this, the mating of horses and donkeys is still possible and has been observed in both domestic and wild settings. However, it is generally discouraged as it can be harmful to both the mare and the jenny, as well as the resulting offspring.
In conclusion, horses and donkeys are closely related and can interbreed, but the resulting offspring is not a true hybrid. Rather, it is a mule or a hinny, depending on the species of the parents. These animals are sterile and unable to reproduce, and the mating of horses and donkeys is generally discouraged as it can be harmful to both the animals and the resulting offspring.