Yes, Sasuke Uchiha, a character from the popular anime and manga series “Naruto,” lost his arm permanently. The loss of his arm occurred during the Fourth Great Ninja War, in which Sasuke was fighting alongside his fellow shinobi against the forces of the Akatsuki organization.

During the war, Sasuke was attacked by one of the members of the Akatsuki, Madara Uchiha, who was attempting to capture the Nine-Tailed Fox inside Naruto Uzumaki. In the course of their battle, Madara used his powerful technique, the Susanoo, to sever Sasuke’s left arm.
While the loss of his arm was undoubtedly a setback for Sasuke, he was able to continue fighting and ultimately played a pivotal role in ending the war. Despite his injury, Sasuke was able to use his remaining abilities, including his Sharingan and Rinnegan eye techniques, to help turn the tide of battle and defeat Madara and other powerful opponents.
After the war, Sasuke continued to live with his disability, and he was shown using various prosthetic devices to assist him in his daily life. However, his missing arm did not prevent him from continuing to pursue his goals, which included seeking redemption for his past actions and protecting the world from threats.
Overall, Sasuke’s loss of his arm was a significant plot development in the “Naruto” series, and it had lasting consequences for both the character and the story as a whole. While he was able to continue fighting and contributing to the story despite his disability, the loss of his arm served as a reminder of the dangers and sacrifices involved in the world of ninja warfare.