Monkey D. Luffy, the protagonist of the popular anime and manga series “One Piece,” does not have a biological sister. He grew up with two brothers, Ace and Sabo, who became his close friends and allies.

However, there is a character in the series who is often mistakenly believed to be Luffy’s sister due to their similar appearance and close relationship. That character is Portgas D. Rouge, the mother of Luffy’s brother Ace.
Portgas D. Rouge was a member of the infamous Gol D. Roger’s pirate crew and the lover of Gol D. Roger, the legendary pirate king. She became pregnant with Ace after meeting Roger and gave birth to him while imprisoned by the World Government. She then entrusted Ace to the care of Monkey D. Garp, Luffy’s grandfather, before dying shortly after.
Although Rouge is not Luffy’s biological sister, she did play an important role in his life and the lives of his brothers. Her sacrifice in giving birth to Ace and hiding his true identity from the World Government allowed him to grow up free from persecution and become a powerful ally to Luffy and his crew.
In addition to Ace and Sabo, Luffy has formed close bonds with many other characters throughout his journey, including his crewmates Nami, Zoro, Sanji, Usopp, Chopper, Robin, Franky, and Brook. Each of these characters has their own unique backstory and motivations, and they have all played important roles in helping Luffy achieve his goal of becoming the pirate king.
Overall, while Luffy does not have a biological sister, he has formed strong bonds with many characters throughout the “One Piece” series, including his brothers Ace and Sabo and his crewmates. These relationships have helped shape Luffy into the determined and loyal pirate he is today.